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Article

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle.

Nucleic acids research - 1 Nov 2004

Schiffelers Raymond M, Ansari Aslam, Xu Jun, Zhou Qin, Tang Qingquan, Storm Gert, Molema Grietje, Lu Patrick Y, Scaria Puthupparampil V, Woodle Martin C

Abstract excerpt

Potent sequence selective gene inhibition by siRNA 'targeted' therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood stability and non-specific immune stimulation. To address these problems, ligand-targeted, sterical...

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Identifiers

PMID: 15520458
DOI: 10.1093/nar/gnh140
PMCID: PMC528817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15520458-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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