Article
Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity.
Nature genetics - 1 Dec 2004
Hiller Michael, Huse Klaus, Szafranski Karol, Jahn Niels, Hampe Jochen, Schreiber Stefan, Backofen Rolf, Platzer Matthias
Abstract excerpt
Splice acceptors with the genomic NAGNAG motif may cause NAG insertion-deletions in transcripts, occur in 30% of human genes and are functional in at least 5% of human genes. We found five significant biases indicating that their distribution is nonrandom and that they are evolutionarily conserved and tissue-specific. Because of their subtle effects on mRNA and protein structures, these splice acceptors are often...
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