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Article

Screening for cystic fibrosis gene mutations by multiplex DNA amplification.

Human genetics - 1 Mar 1992

Picci L, Anglani F, Scarpa M, Zacchello F

Abstract excerpt

We have developed a simple rapid DNA screening test that allows us simultaneously to analyze seven CF mutations (delta F508, R347P, S549N, G551D, R553X, R334W, 444delA) that together account for about 60% of all CF mutations in the Italian population. It consists of three steps: multiplex polymerase chain reaction (PCR) amplification of exons 4, 7, 10 and 11; restriction endonuclease digestion of the PCR...

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PMID: 1551658
DOI: 10.1007/BF00219343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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