Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recurrent small-artery disease in hyperhomocysteinemia: widowers' stroke syndrome?

Internal medicine (Tokyo, Japan) - 1 Sept 2004

Toyoda Kazunori, Uwatoko Takeshi, Shimada Toshifumi, Hagiwara Noriko, Fujimoto Shigeru, Ibayashi Setsuro, Okada Yasushi

Abstract excerpt

Hyperhomocysteinemia is thought to cause ischemic strokes. We report two middle-aged widowers with frequent recurrences of small-artery strokes, two capsular infarcts and a thalamic hemorrhage in one patient, and two thalamic and pontine infarcts in the other. Blood tests following the final stroke showed hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T gene mutation, with low concentration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Hemorrhage
Share to Cerebral Infarction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperhomocysteinemia

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Mutation

Share to Recurrence

Share to Stroke

Source

Identifiers

PMID: 15497528
DOI: 10.2169/internalmedicine.43.869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recurrent small-artery disease in hyperhomocysteinemia: widowers' stroke syndrome?PMID 15497528Read ↗

High plasma homocysteine levels contribute to the risk of stroke recurrence and all-cause mortality in a large prospective stroke population.Semantic proximity Read ↗

Recurrent strokes in a 34-year-old man.Semantic proximity Read ↗

Platelet glycoprotein receptor IIIa polymorphism P1A2 and ischemic stroke risk: the Stroke Prevention in Young Women Study.Semantic proximity Read ↗

Recurrent Paradoxical Embolism and Manganese Deposition in the Basal Ganglia in a Patient with Hereditary Haemorrhagic Telangiectasias: A Case Report and Literature ReviewSemantic proximity Read ↗

Stroke in vascular Ehlers-Danlos syndrome.Semantic proximity Read ↗

Hyperhomocysteinemia is related to large vessel occlusion in young patients with COVID-19, two case reportsSemantic proximity Read ↗

Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study.Semantic proximity Read ↗

Short telomere length in blood leucocytes contributes to the presence of atherothrombotic stroke and haemorrhagic stroke and risk of post-stroke deathSemantic proximity Read ↗

Preventing a second stroke in the young.Semantic proximity Read ↗

Arterial ischemic stroke in an adolescent with presumed perinatal ischemic stroke.Semantic proximity Read ↗

Prevention and management of strokes in patients with sickle cell disease.Semantic proximity Read ↗

Recurrent intracerebral hemorrhage in patients with hypertension is associated with APOE gene polymorphism: a preliminary study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.