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Article

Iron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis.

The American journal of clinical nutrition - 1 Oct 2004

Hunt Janet R, Zeng Huawei

Abstract excerpt

BACKGROUND: Research conducted before genotyping was possible suggested that subjects heterozygous for the genetic mutation associated with hemochromatosis absorbed nonheme iron more efficiently than did control subjects when tested with a fortified meal. Heme-iron absorption in these subjects has not been reported. OBJECTIVE: We compared the absorption of heme and nonheme iron from minimally or highly fortified...

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Share to Anemia, Iron-Deficiency
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15447900
DOI: 10.1093/ajcn/80.4.924

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Iron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis.PMID 15447900Read ↗

Iron absorption in male C282Y heterozygotes.Semantic proximity Read ↗

HFE genotype modifies the influence of heme iron intake on iron status.Semantic proximity Read ↗

Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation.Semantic proximity Read ↗

Haptoglobin type neither influences iron accumulation in normal subjects nor predicts clinical presentation in HFE C282Y haemochromatosis: phenotype and genotype analysis.Semantic proximity Read ↗

HFE genotypes and dietary heme iron: no evidence of strong gene-nutrient interaction on serum ferritin concentrations in middle-aged women.Semantic proximity Read ↗

Compound heterozygous hemochromatosis genotype predicts increased iron and erythrocyte indices in women.Semantic proximity Read ↗

High prevalence of the hemochromatosis-associated Cys282Tyr HFE gene mutation in a healthy Norwegian population in the city of Oslo, and its phenotypic expression.Semantic proximity Read ↗

HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity # †Semantic proximity Read ↗

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