Article
Association between the neurofibromatosis-1 (NF1) locus and autism in the Japanese population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Nov 2004
Marui Tetsuya, Hashimoto Ohiko, Nanba Eiji, Kato Chieko, Tochigi Mamoru, Umekage Tadashi, Ishijima Michiko, Kohda Kazuhisa, Kato Nobumasa, Sasaki Tsukasa
Abstract excerpt
Autistic patients have a 100 to 190-fold increased risk of neurofibromatosis compared to the general population. This suggests that the two diseases may share a common etiological background. Recently, a new allele (or the six-repeat allele) of the (AAAT)(n) repeat polymorphism in an Alu sequence in the neurofibromatosis-1 (NF1) gene was observed exclusively in severe autistic patients, not in controls, in...
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