Article
A large erythroid spectrin beta-chain variant.
British journal of haematology - 1 Jan 1992
Johnson R M, Ravindranath Y, Brohn F, Hussain M
Abstract excerpt
A large variant of erythrocyte beta-spectrin was found in a child presenting with hereditary elliptocytosis and anaemia. This polypeptide was phosphorylated, cross-reacted with normal beta-spectrin in immunoblotting and formed a dimer with alpha-spectrin that co-purified with normal alpha beta dimer. The molecular weight was estimated to be 330 kD by SDS gel electrophoresis, which is 84 kD (35%) larger than the...
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