A large erythroid spectrin beta-chain variant.

doi:10.1111/j.1365-2141.1992.tb06393.x

Back to search

Article

A large erythroid spectrin beta-chain variant.

British journal of haematology - 1 Jan 1992

Johnson R M, Ravindranath Y, Brohn F, Hussain M

Abstract excerpt

A large variant of erythrocyte beta-spectrin was found in a child presenting with hereditary elliptocytosis and anaemia. This polypeptide was phosphorylated, cross-reacted with normal beta-spectrin in immunoblotting and formed a dimer with alpha-spectrin that co-purified with normal alpha beta di...

Topics

Centrifugation, Density Gradient
Electrophoresis, Polyacrylamide Gel
Elliptocytosis, Hereditary
Erythrocyte Deformability
Erythrocytes
Humans
Male
Molecular Weight
Mutation
Osmotic Fragility
Pedigree
Spectrin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.