Article
A patch of surface-exposed residues mediates negative regulation of immune signaling by tomato Pto kinase.
The Plant cell - 1 Oct 2004
Wu Ai-Jiuan, Andriotis Vasilios M E, Durrant Marcus C, Rathjen John P
Abstract excerpt
Tomato (Lycopersicon esculentum) Pto kinase specifically recognizes the Pseudomonas effector proteins AvrPto and AvrPtoB, leading to induction of defense responses and hypersensitive cell death. Structural modeling of Pto combined with site-directed mutagenesis identified a patch of surface-exposed residues required for native regulation of signaling. Mutations in this area resulted in constitutive...
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