Article
Carnitine-acylcarnitine translocase deficiency, clinical, biochemical and genetic aspects.
Molecular aspects of medicine - 1 Jan 2000
Rubio-Gozalbo M E, Bakker J A, Waterham H R, Wanders R J A
Abstract excerpt
The carnitine-acylcarnitine translocase (CACT) is one of the components of the carnitine cycle. The carnitine cycle is necessary to shuttle long-chain fatty acids from the cytosol into the intramitochondrial space where mitochondrial beta-oxidation of fatty acids takes place. The oxidation of fatty acids yields acetyl-coenzyme A (CoA) units, which may either be degraded to CO(2) and H(2)O in the citric acid cycle...
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