Article
Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity.
Biochemical and biophysical research communications - 8 Oct 2004
Horibe Tomohisa, Matsui Hiroaki, Tanaka Mami, Nagai Hiroaki, Yamaguchi Yoshiki, Kato Koichi, Kikuchi Masakazu
Abstract excerpt
Recently, it became clear that aminoglycoside antibiotics affect protein-protein interactions involving protein disulfide isomerase as well as protein synthesis in the endoplasmic reticulum. In this study, we used affinity column chromatography to screen gentamicin-binding proteins in microsomes derived from bovine kidney in order to learn about the possible mechanisms of gentamicin-associated nephrotoxicity. One...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.