Article
Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells.
Biochemical and biophysical research communications - 8 Oct 2004
Miyata Tomohiko, Ohnishi Hirohide, Suzuki Junko, Yoshikumi Yukako, Ohno Hideki, Mashima Hirosato, Yasuda Hiroshi, Ishijima Takako, Osawa Hiroyuki, Satoh Kiichi, Sunada Keijiro, Kita Hiroto, Yamamoto Hironori, Sugano Kentaro
Abstract excerpt
Membrane-type 1 matrix metalloproteinase (MT1-MMP) localized on the plasma membrane plays a central role in various normal biological responses including tissue remodeling, wound heeling, and angiogenesis and in cancer cell invasion and metastasis, by functioning as a collagenase and activating other matrix metalloproteinases. In order to elucidate the molecular mechanism of the MT1-MMP targeted localization on...
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