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Article

The effects of BRCA1 missense variants V1804D and M1628T on transcriptional activity.

Cancer genetics and cytogenetics - 1 Sept 2004

Ostrow Kimberly Laskie, McGuire Valerie, Whittemore Alice S, DiCioccio Richard A

Abstract excerpt

Many families with multiple cases of ovarian cancer, breast cancer, or both segregate inherited mutations in one allele of the tumor suppressor gene BRCA1. Genetic testing is used to assess cancer risk; however, testing can detect missense DNA alterations, called unclassified variants, of unknown functional and biological significance with uncertain risk implications. Some missense variants at the transcriptional...

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Source

Identifiers

PMID: 15350310
DOI: 10.1016/j.cancergencyto.2004.01.020

Genes

BRCA1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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