Article
Genetic basis of tobacco smoking: strong association of a specific major histocompatibility complex haplotype on chromosome 6 with smoking behavior.
International immunology - 1 Oct 2004
Füst George, Arason Gudmundur J, Kramer Judith, Szalai Csaba, Duba Jeno, Yang Yan, Chung Erwin K, Zhou Bi, Blanchong Carol A, Lokki Marja-Liisa, Bödvarsson Sigurdur, Prohászka Zoltán, Karádi István, Vatay Agnes, Kovács Margit, Romics László, Thorgeirsson Gudmundur, Yu C Yung
Abstract excerpt
The genetic basis for addiction to tobacco smoking--particularly that of the perception of olfactory stimuli that may be important in reinforcing smoking addiction--is largely unknown. A cluster of genes for olfactory receptors is in close proximity to the MHC region on chromosome 6. Polymorphisms of MHC class III genes (RCCX modules, TNFA promoter polymorphisms) were determined in 101 healthy subjects and 232...
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