Article
MHC-linked olfactory receptor loci exhibit polymorphism and contribute to extended HLA/OR-haplotypes.
Genome research - 1 Dec 2000
Ehlers A, Beck S, Forbes S A, Trowsdale J, Volz A, Younger R, Ziegler A
Abstract excerpt
Clusters of olfactory receptor (OR) genes are found on most human chromosomes. They are one of the largest mammalian multigene families. Here, we report a systematic study of polymorphism of OR genes belonging to the largest fully sequenced OR cluster. The cluster contains 36 OR genes, of which two belong to the vomeronasal 1 (V1-OR) family. The cluster is divided into a major and a minor region at the telomeric...
Topics
- Alleles
- Amino Acid Substitution
- Cell Line
- Chemotactic Factors
- Gene Order
- Genes
- Genetic Linkage
- HLA Antigens
- Haplotypes
- Humans
- Major Histocompatibility Complex
- Molecular Sequence Data
- Multigene Family
- Open Reading Frames
- Polymorphism, Genetic