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Article

Dam inactivation in Neisseria meningitidis: prevalence among diverse hyperinvasive lineages.

BMC microbiology - 31 Aug 2004

Jolley Keith A, Sun Li, Moxon E Richard, Maiden Martin C J

Abstract excerpt

BACKGROUND: DNA adenine methyltransferase (Dam) activity is absent in many, but not all, disease isolates of Neisseria meningitidis, as a consequence of the insertion of a restriction endonuclease-encoding gene, the 'dam replacing gene' (drg) at the dam locus. Here, we report the results of a survey to assess the prevalence of drg in a globally representative panel of disease-associated meningococci. RESULTS: Of...

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Identifiers

PMID: 15339342
DOI: 10.1186/1471-2180-4-34
PMCID: PMC516771

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Source receipt: pubmed, retrieved 7 Sept 2026.

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