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Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia

25 Aug 2004

Abstract excerpt

BACKGROUND: Farnesyl protein transferase inhibitors (FTIs) were originally developed to inhibit oncogenic ras, however it is now clear that there are several other potential targets for this drug class. The FTI tipifarnib (ZARNESTRA, R115777) has recently demonstrated clinical responses in adults with refractory and relapsed acute leukemias. This study was conducted to identify genetic markers and pathways that...

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PMID: 15329151
DOI: 10.1186/1471-2407-4-56

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