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Beta-thalassaemia-87 C-->G: relationship of the Hb F modulation and polymorphisms in compound heterozygous patients.

British journal of haematology - 1 Sept 2004

De Angioletti Maria, Lacerra Giuseppina, Pagano Leonilde, Alessi Mario, D'Avino Rossana, Manca Laura, Carestia Clementina

Abstract excerpt

A clinical, haematological, biochemical and molecular study was carried out in 17 patients affected with thalassaemia intermedia, who were compound heterozygotes for the beta-thalassaemia mutation beta-87 C-->G to determine the genetic basis of their clinical heterogeneity. The beta-87 was found associated with haplotype VIII (beta-87/VIII) or V (beta-87/V). The 10 patients with the beta-87/VIII showed milder...

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Identifiers

PMID: 15327529
DOI: 10.1111/j.1365-2141.2004.05089.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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