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Article

NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression

20 Aug 2004

Abstract excerpt

Primordial ovarian follicles in mice form when somatic cells surround individual oocytes. We show that lack of Nobox, an oocyte-specific homeobox gene, accelerates postnatal oocyte loss and abolishes the transition from primordial to growing follicles in mice. Follicles are replaced by fibrous tissue in female mice lacking Nobox in a manner similar to nonsyndromic ovarian failure in women. Genes preferentially...

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Identifiers

PMID: 15326356
DOI: 10.1126/science.1099755

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NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene ExpressionPMID 15326356Read ↗

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Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdownSemantic proximity Read ↗

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