Article
Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients.
Clinical rheumatology - 1 Aug 2004
Frank Bernd, Niesler Beate, Bondy Brigitta, Späth Michael, Pongratz Dieter E, Ackenheil Manfred, Fischer Christine, Rappold Gudrun
Abstract excerpt
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in numerous human disorders. Dysfunction of serotonergic neurotransmission is thought to play a major role in the pathophysiology of the fibromyalgia syndrome (FMS) which is characterised by non-restorative sleep and severe pain. In our study, both serotonin receptor subunit genes, HTR3A and HTR3B, have been investigated for sequence...
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