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Article

Imperfect CAG repeats form diverse structures in SCA1 transcripts.

The Journal of biological chemistry - 1 Oct 2004

Sobczak Krzysztof, Krzyzosiak Wlodzimierz J

Abstract excerpt

The expanded CAG repeat in the coding sequence of the spinocerebellar ataxia type 1 (SCA1) gene is responsible for SCA1, one of the hereditary human neurodegenerative diseases. In the normal SCA1 alleles usually 1-3 CAT triplets break the continuity of the CAG repeat tracts. Here we show what is the structural role of the CAU interruptions in the SCA1 transcripts. Depending on their number and localization within...

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Source

Identifiers

PMID: 15292212
DOI: 10.1074/jbc.M405130200

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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