Article
Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient.
AIDS (London, England) - 20 Aug 2004
Gouskos Theo, Wightman Fiona, Chang Judy, Earnest-Silveira Linda, Sasadeusz Joseph, Lewin Sharon R, Torresi Joseph
Abstract excerpt
We describe here a severe flare of hepatitis caused by lamivudine-resistant hepatitis B virus(HBV) in an HIV/HBV co-infected individual.Lamivudine-resistant HBV was detected 6 months before the development of severe hepatitis. Sequencing of the HBV genome isolated from the patients' serum did not identify compensatory mutations in the HBV polymerase that may have restored viral replication. However, a strong...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.