Article
Association study of the Epac gene and tobacco smoking and nicotine dependence.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Aug 2004
Chen Xiangning, Wu Baichai, Kendler Kenneth S
Abstract excerpt
Exchange protein directly activated by cAMP (Epac) has been shown to increase its expression in rat prefrontal cortex after self-administration of nicotine. [Konu et al. 2001: Brain Res 909:194-203]. We investigated the role of the human ortholog of Epac in tobacco smoking and nicotine dependence (ND). Using a case-control design, we typed 5 SNPs in this gene in 688 subjects, of whom 244 were non-smokers, 215...
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