Article
Protozoan predation, diversifying selection, and the evolution of antigenic diversity in Salmonella.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004
Wildschutte Hans, Wolfe David M, Tamewitz Aletheia, Lawrence Jeffrey G
Abstract excerpt
Extensive population-level genetic variability at the Salmonella rfb locus, which encodes enzymes responsible for synthesis of the O-antigen polysaccharide, is thought to have arisen through frequency-dependent selection (FDS) by means of exposure of this pathogen to host immune systems. The FDS hypothesis works well for pathogens such as Haemophilus influenzae and Neisseria meningitis, which alter the...
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