Article
Mutation analysis of the RECQL4 gene in sporadic osteosarcomas.
International journal of cancer - 1 Sept 2004
Nishijo Koichi, Nakayama Tomitaka, Aoyama Tomoki, Okamoto Takeshi, Ishibe Tatsuya, Yasura Ko, Shima Yasuko, Shibata Kotaro R, Tsuboyama Tadao, Nakamura Takashi, Toguchida Junya
Abstract excerpt
Osteosarcoma (OS) is the most prevalent malignant tumor among cases of Rothmund-Thomson syndrome (RTS) with germline mutations of the RECQL4 gene, a member of the RecQ helicase family. We investigated the involvement of the RECQL4 gene in the development of OS unrelated to RTS. RECQL4 mRNA was detected in 9 of 9 OS cell lines by Northern blotting and 26 of 26 OS tumors by RT-PCR. Direct sequencing of the entire...
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