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Article

The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities.

The Journal of biological chemistry - 27 Aug 2004

Yakunin Alexander F, Proudfoot Michael, Kuznetsova Ekaterina, Savchenko Alexei, Brown Greg, Arrowsmith Cheryl H, Edwards Aled M

Abstract excerpt

In all mature tRNAs, the 3'-terminal CCA sequence is synthesized or repaired by a template-independent nucleotidyltransferase (ATP(CTP):tRNA nucleotidyltransferase; EC 2.7.7.25). The Escherichia coli enzyme comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity...

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PMID: 15210699
DOI: 10.1074/jbc.M405120200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15210699-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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