Article
Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo.
The European journal of neuroscience - 1 May 2004
Klyubin Igor, Walsh Dominic M, Cullen William K, Fadeeva Julia V, Anwyl Roger, Selkoe Dennis J, Rowan Michael J
Abstract excerpt
Mutations in the amyloid precursor protein that result in substitutions of glutamic acid at residue 22 of the amyloid beta protein (A beta) with glutamine (Q22, Dutch) or glycine (G22, Arctic) cause aggressive familial neurological diseases characterized by cerebrovascular haemorrhages or Alzheimer's-type dementia, respectively. The present study compared the ability of these peptides to block long-term...
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