Article
An extensive metabolizer with recurrent ulcer responding to high dose of lansoprazole.
Hepato-gastroenterology - 1 Jan 2000
Higuchi Katsuhiko, Tanabe Satoshi, Koizumi Wasaburo, Nakayama Norisuke, Sasaki Tohru, Nagaba Shizuka, Saigenji Katsunori, Katada Natsuya
Abstract excerpt
A 51-year-old man underwent surgery for duodenal ulcer in 1983. Ulcer recurred several times. Recently, the patient was receiving 30 mg/day of lansoprazole. On June 15, 2001 hemorrhagic recurrent ulcer was diagnosed. Analysis of CYP2C19 enzyme genotype indicated that the patient was a heterozygous extensive metabolizer, suggesting that 30 mg/day of lansoprazole did not produce effective concentrations of drug in...
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