Article
Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine.
Neurology - 11 May 2004
Strupp M, Kalla R, Dichgans M, Freilinger T, Glasauer S, Brandt T
Abstract excerpt
Patients with episodic ataxia type 2 (EA2) can often be successfully treated with acetazolamide. The authors report three patients with EA2 (two with proven mutations in the CACNA1A gene) whose attacks were prevented with the potassium channel blocker 4-aminopyridine (4-AP; 5 mg tid). Attacks recurred after treatment was stopped; subsequent treatment alleviated the symptoms (mean follow-up time 6 months). These...
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