Article
Molecular basis for the apparent mineralocorticoid excess syndrome in the Oman population.
Molecular and cellular endocrinology - 31 Mar 2004
Quinkler M, Bappal B, Draper N, Atterbury A J, Lavery G G, Walker E A, DeSilva V, Taylor N F, Hala S, Rajendra N, Stewart P M
Abstract excerpt
11beta-Hydroxysteroid dehydrogenase type 2 (11beta-HSD2) plays a crucial role in converting hormonally active cortisol to inactive cortisone, thereby conferring specificity upon the mineralocorticoid receptor (MR). Mutations in the gene encoding 11beta-HSD2 (HSD11B2) account for an inherited form of hypertension, the syndrome of "Apparent Mineralocorticoid Excess" (AME) where cortisol induces hypertension and...
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