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Article

Denaturing HPLC-based approach for detecting RYR2 mutations involved in malignant arrhythmias.

Clinical chemistry - 1 Jul 2004

Bagattin Alessia, Veronese Caterina, Bauce Barbara, Wuyts Wim, Settimo Luca, Nava Andrea, Rampazzo Alessandra, Danieli Gian Antonio

Abstract excerpt

BACKGROUND: Mutations in the RYR2 gene, which encodes the cardiac ryanodine receptor, have been reported in patients showing either arrhythmogenic right ventricular cardiomyopathy, type 2, or stress-induced polymorphic ventricular tachycardia. Both clinical phenotypes are characterized by a high risk of sudden death. Detection of RYR2 mutations is particularly important because beta-blocker treatment has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromatography, High Pressure Liquid

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Source

Identifiers

PMID: 15131021
DOI: 10.1373/clinchem.2003.030734

Genes

RYR2
RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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