Detection of single nucleotide polymorphisms in the mannose-binding lectin gene using minor groove binder-DNA probes.

doi:10.1016/j.jim.2004.01.025

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Article

Detection of single nucleotide polymorphisms in the mannose-binding lectin gene using minor groove binder-DNA probes.

Journal of immunological methods - 1 Apr 2004

Van Hoeyveld Erna, Houtmeyers Frans, Massonet Caroline, Moens Leen, Van Ranst Marc, Blanckaert N, Bossuyt Xavier

Abstract excerpt

Structural point mutations in exon 1 at codons 52, 54 and 57 and a promotor polymorphism at -221 bp of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to various infectious diseases. We developed a genotyping method based on the 5' nuclease (TaqMan) assay in combination with the use of minor-groove-binder (MGB) probes in screening for these mutations/polymorphisms. In contrast...

Topics

DNA Primers
DNA Probes
Genotype
Humans
Mannose-Binding Lectin
Molecular Probe Techniques
Point Mutation
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Sensitivity and Specificity
Taq Polymerase

Source

Open in PubMed

Identifiers

PMID: 15099770
DOI: 10.1016/j.jim.2004.01.025

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