Article
A polymorphism in the poliovirus receptor gene differs in motor neuron disease.
Neuroreport - 9 Feb 2004
Saunderson Rebecca, Yu Bing, Trent Ronald J, Pamphlett Roger
Abstract excerpt
Poliovirus has been implicated in the etiology of sporadic motor neuron disease. DNA polymorphisms in the poliovirus receptor gene (PVR) are associated with persistent poliovirus infection in cell culture. PVR DNA polymorphisms were therefore studied in 110 cases of amyotrophic lateral sclerosis, 30 cases of progressive muscular atrophy (a disorder of lower motor neurons) and 280 normal controls. In exon 2 of PVR...
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