Article
The genetics of autoimmune-mediated rheumatic diseases: clinical and biologic implications.
Rheumatic diseases clinics of North America - 1 Feb 2004
Winchester Robert
Abstract excerpt
This article emphasizes the interpretation of the meaning and significance of the genetic aspects of susceptibility to certain autoimmune-mediated rheumatic diseases. The familial aggregation and identical twin concordance that provides the basis of considering these as genetic diseases are reviewed. Major histocompatibility complex (MHC) genes are taken as the primary examples of candidate genes that regulate...
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