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Article

Regulatory potential scores from genome-wide three-way alignments of human, mouse, and rat.

Genome research - 1 Apr 2004

Kolbe Diana, Taylor James, Elnitski Laura, Eswara Pallavi, Li Jia, Miller Webb, Hardison Ross, Chiaromonte Francesca

Abstract excerpt

We generalize the computation of the Regulatory Potential (RP) score from two-way alignments of human and mouse to three-way alignments of human, mouse, and rat. This requires overcoming technical challenges that arise because the complexity of the models underlying the score increases exponentially with the number of species. Despite the close evolutionary proximity of rat to mouse, we find that adding the rat...

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Identifiers

PMID: 15060013
DOI: 10.1101/gr.1976004
PMCID: PMC383316

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