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Article

Paroxetine retards disease onset and progression in Huntingtin mutant mice.

Annals of neurology - 1 Apr 2004

Duan Wenzhen, Guo Zhihong, Jiang Haiyang, Ladenheim Bruce, Xu Xiangru, Cadet Jean Lud, Mattson Mark P

Abstract excerpt

We report that administration of paroxetine, a widely prescribed antidepressant drug that acts by inhibiting reuptake of the neurotransmitter serotonin, suppresses the neurodegenerative process and increases the survival of huntingtin mutant mice, an animal model of Huntington's disease (HD). Par...

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Identifiers

PMID: 15048901
DOI: 10.1002/ana.20075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15048901-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Paroxetine retards disease onset and progression in Huntingtin mutant mice.PMID 15048901Read ↗

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