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Article

Conformation of prion protein repeat peptides probed by FRET measurements and molecular dynamics simulations.

Biophysical journal - 1 Apr 2004

Gustiananda Marsia, Liggins John R, Cummins Peter L, Gready Jill E

Abstract excerpt

We report the combined use of steady-state fluorescence resonance energy transfer (FRET) experiments and molecular dynamics (MD) simulations to investigate conformational distributions of the prion protein (PrP) repeat system. FRET was used for the first time to probe the distance, as a function of temperature and pH, between a donor Trp residue and an acceptor dansyl group attached to the N-terminus in seven...

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Identifiers

PMID: 15041684
DOI: 10.1016/S0006-3495(04)74303-9
PMCID: PMC1304095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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