Article
Functional aspects of cellular microcompartmentation in the development of neurodegeneration: mutation induced aberrant protein-protein associations.
Molecular and cellular biochemistry - 1 Jan 2000
Ovádi Judit, Orosz Ferenc, Hollán Susan
Abstract excerpt
Research in the last 10 years has revealed that the development of neurodegeneration is a multistep process during which one or few specific mutant protein species of altered conformation initiate aberrant protein-protein interactions resulting in aggregates forming plaques. This review focuses on the heteroassociations of the mutant proteins with subcellular structures, such as cytoskeleton, cell membranes or...
Topics
- Animals
- Brain
- Central Nervous System
- Glycolysis
- Humans
- Microtubules
- Mutation
- Protein Binding
- Proteins