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Article

Functional Analysis of cis-Acting Elements Regulating the Alternative Splicing of Human CFTR Exon 9

1 Dec 1999

Abstract excerpt

The rate of exon 9 exclusion from the cystic fibrosis transmembrane conductance regulator (CFTR) mRNA is associated with monosymptomatic forms of cystic fibrosis. Exon 9 alternative splicing is modulated by a polymorphic polythymidine tract within its 3' splice site. We have generated a minigene carrying human CFTR exon 9 with its flanking intronic sequences and set up an in vivo model to study the cis-acting DNA...

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Identifiers

PMID: 10556281
DOI: 10.1093/hmg/8.13.2339

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Functional Analysis of cis-Acting Elements Regulating the Alternative Splicing of Human CFTR Exon 9PMID 10556281Read ↗

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