Hb Graz or alpha 2 beta 2(2)(NA2)His-->Leu; a new beta chain variant observed in four families from southern Austria.

doi:10.3109/03630269208993117

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Article

Hb Graz or alpha 2 beta 2(2)(NA2)His-->Leu; a new beta chain variant observed in four families from southern Austria.

Hemoglobin - 1 Jan 1992

Liu J S, Molchanova T P, Gu L H, Wilson J B, Hopmeier P, Schnedl W, Balaun E, Krejs G J, Huisman T H

Abstract excerpt

Two abnormal hemoglobins were accidentally detected by cation exchange high performance liquid chromatography with the Diamat system of Bio-Rad Laboratories; the variants eluted together with the fast-moving Hb A1c. Structural analysis of isolated beta chains and sequence analysis of amplified DN...

Topics

Amino Acid Sequence
Austria
Base Sequence
Genetic Variation
Hemoglobins, Abnormal
Heterozygote
Humans
Molecular Sequence Data
Mutation
Peptide Fragments

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