Article
Type II diabetes: search for primary defects.
Annals of medicine - 1 Dec 1992
Turner R, Hattersley A, Cook J
Abstract excerpt
Type 2 diabetes is a familial disease, but recent analysis of nuclear families indicates it is unlikely to be due to a single dominant gene with high penetrance and that it could be polygenic. Insulin resistance is a major feature, with obesity being a major determinant. Beta cell deficiency is a sine qua non of Type 2 diabetes. It is possible that obesity, insulin resistance independent from obesity and impaired...
Topics
- Diabetes Mellitus, Type 2
- Humans
- Insulin Resistance
- Islets of Langerhans
- Mutation