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Article

Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus

9 Feb 2004

Abstract excerpt

The 1918 "Spanish" influenza pandemic represents the largest recorded outbreak of any infectious disease. The crystal structure of the uncleaved precursor of the major surface antigen of the extinct 1918 virus was determined at 3.0 angstrom resolution after reassembly of the hemagglutinin gene from viral RNA fragments preserved in 1918 formalin-fixed lung tissues. A narrow avian-like receptor-binding site, two...

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PMID: 14764887
DOI: 10.1126/science.1093373

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