Article
Association of cystic fibrosis with abnormalities in fatty acid metabolism.
The New England journal of medicine - 5 Feb 2004
Freedman Steven D, Blanco Paola G, Zaman Munir M, Shea Julie C, Ollero Mario, Hopper Isabel K, Weed Deborah A, Gelrud Andres, Regan Meredith M, Laposata Michael, Alvarez Juan G, O'Sullivan Brian P
Abstract excerpt
BACKGROUND: Patients with cystic fibrosis have altered levels of plasma fatty acids. We previously demonstrated that arachidonic acid levels are increased and docosahexaenoic acid levels are decreased in affected tissues from cystic fibrosis-knockout mice. In this study we determined whether humans with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have a similar fatty acid...
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