Article
Non- HFE hemochromatosis
1 Jan 2004
Abstract excerpt
The term ‘hemochromatosis’ refers to an autosomal recessive disorder of iron metabolism associated with two mutant alleles of the HFE gene (usually leading to a Cys282Tyr mutation in the gene product) and characterized by a slow and progressive increase in plasma iron content, which, in adults, may lead to systemic iron loading of parenchymal cells (particularly hepatocytes) and, eventually, to organ disease. In...
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