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Article

The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo.

Journal of virology - 1 Feb 2004

Peh Woei L, Brandsma Janet L, Christensen Neil D, Cladel Nancy M, Wu Xing, Doorbar John

Abstract excerpt

Expression of the papillomavirus E4 protein correlates with the onset of viral DNA amplification. Using a mutant cottontail rabbit papillomavirus (CRPV) genome incapable of expressing the viral E4 protein, we have shown that E4 is required for the productive stage of the CRPV life cycle in New Zealand White and cottontail rabbits. In these lesions, E4 was not required for papilloma development, but the onset of...

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Identifiers

PMID: 14747580
DOI: 10.1128/jvi.78.4.2142-2151.2004
PMCID: PMC369506

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Source receipt: pubmed, retrieved 7 Sept 2026.

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