Article
Induction of CD4+ murine natural killer T-like cells by immunization with syngeneic thymoma expressing embryonic alpha-fetoprotein.
Cellular immunology - 1 Nov 2003
Kim Youngsoon, Nakagawa Yohko, Sugiyama Hirotaka, Shimizu Masumi, Takeshita Toshiyuki, Araki Tsutomu, Takahashi Hidemi
Abstract excerpt
In embryo, before the establishment of acquired immunity, a variety of embryonic antigens like alpha-fetoprotein (AFP) are produced and secreted in the sera, which rapidly disappear after the birth. Such embryonic antigens sometimes reappear from various tumor cells and decrease in the case of remission, indicating embryonic antigens may alert immune system to control tumors. In the present study, to examine the...
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