Article
[Paraganglioma in the area of the head and neck. A review of molecular genetic research].
HNO - 1 Jan 2004
Braun S, Riemann K, Pusch C M, Sotlar K, Pfister M, Kupka S
Abstract excerpt
Paragangliomas of the head and neck region are usually benign tumors that develop from chemoreceptors of paraganglionic origin in the majority of patients. These receptors play an important role in sensing and regulation of the blood CO(2) level. Genetic alterations in the mitochondrial enzyme complex II (SDH), which is involved in respiratory chain and citric acid cycle reactions, have been shown to lead to...
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