Article
[Molecular mechanisms of two novel mutations of factor XIII gene resulting in hereditary coagulation deficiency].
Zhonghua yi xue za zhi - 25 Dec 2003
Duan Bao-hua, Wang Hong-li, Wang Xue-feng, Hu Yi-qun, Chu Hai-yan, Wang Hong, Yin Jun, Guo Xue-mei, Fu Qi-hua, Wu Wen-man, Ding Qiu-lan, Fang Yi, Wang Wen-bin, Zhou Rong-fu, Kang Wen-ying, Xie Shuang, Wang Zhen-yi
Abstract excerpt
OBJECTIVE: To investigate the mechanisms of two novel missense mutations of factor XIIIA subunit gene (Arg77-->Cys,Ser413-->Trp) in the pathogenesis of hereditary factor XIII deficiency. METHODS: Site-directed mutagenesis was conducted to obtain 2 mutant human XIII A recombinant plasmids, mut-PCI...
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