Article
Increased risk for polycystic ovary syndrome associated with human leukocyte antigen DQA1*0501.
American journal of obstetrics and gynecology - 1 Dec 1992
Ober C, Weil S, Steck T, Billstrand C, Levrant S, Barnes R
Abstract excerpt
OBJECTIVE: The objective of this investigation was to identify genes that confer susceptibility to polycystic ovary syndrome. STUDY DESIGN: Nineteen subjects with polycystic ovary syndrome, hirsutism, and elevated plasma androgen levels and 46 fertile, female control subjects were studied. Alleles at the human leukocyte antigen DQA1 locus were identified with dot-blot hybridizations with allele-specific...
Topics
- Alleles
- Female
- Genetic Predisposition to Disease
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- Homozygote
- Humans
- Male
- Odds Ratio
- Polycystic Ovary Syndrome