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Article

Analysis of cellular localization and function of carboxy-terminal mutants of pendrin.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2011

Bizhanova Aigerim, Chew Teng-Leong, Khuon Satya, Kopp Peter

Abstract excerpt

BACKGROUND: Iodide uptake at the basolateral membrane and iodide efflux at the apical membrane of thyrocytes, essential steps in the biosynthesis of thyroid hormone, are stimulated by thyroid stimulating hormone (TSH). Pendrin (SLC26A4) is inserted into the apical membrane of thyrocytes and thought to be involved in mediating iodide efflux. METHODS: We determined the effects of carboxy-terminal mutations of...

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Share to Cyclic AMP-Dependent Protein Kinases
Share to Iodides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

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Share to Protein Structure, Tertiary

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Identifiers

PMID: 22116356
DOI: 10.1159/000335105
PMCID: PMC3709185

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Related research

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Analysis of cellular localization and function of carboxy-terminal mutants of pendrin.PMID 22116356Read ↗

Genetics and phenomics of Pendred syndrome.Semantic proximity Read ↗

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Mutations of the PDS gene, encoding pendrin, are associated with protein mislocalization and loss of iodide efflux: implications for thyroid dysfunction in Pendred syndrome.Semantic proximity Read ↗

Mutations of the PDS Gene, Encoding Pendrin, Are Associated with Protein Mislocalization and Loss of Iodide Efflux: Implications for Thyroid Dysfunction in Pendred SyndromeSemantic proximity Read ↗

Functional characterization of wild-type and a mutated form of SLC26A4 identified in a patient with Pendred syndrome.Semantic proximity Read ↗

Controversies concerning the role of pendrin as an apical iodide transporter in thyroid follicular cells.Semantic proximity Read ↗

Clinical and molecular characteristics of Pendred syndrome.Semantic proximity Read ↗

Functional characterization of pendrin in a polarized cell system. Evidence for pendrin-mediated apical iodide efflux.Semantic proximity Read ↗

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Mutations in the Pendred Syndrome (PDS/SLC26A) Gene: An Increasingly Complex Phenotypic Spectrum From Goiter to Thyroid HypoplasiaSemantic proximity Read ↗

The role of pendrin in iodide regulation.Semantic proximity Read ↗

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