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Article

Monitoring the inheritance of heteroplasmy by computer-assisted detection of mixed basecalls in the entire human mitochondrial DNA control region.

International journal of legal medicine - 1 Feb 2004

Brandstätter Anita, Niederstätter Harald, Parson Walther

Abstract excerpt

The entire mitochondrial DNA control region (approximately 1122 bp) of 270 blood samples (135 mother-child pairs) was determined by direct sequencing. Overall, 135 'generational events' were screened and within these, 20 mother-offspring pairs demonstrated more than 1 mtDNA haplotype. In 13 families, differences in the haplotypes between mother and offspring were detected in the form of heteroplasmic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 14714189
DOI: 10.1007/s00414-003-0418-z

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